Publications

MethSemble-6mA: An Ensemble-based 6mA Prediction Server and Its Application on Promoter Region of LBD Gene Family in Poaceae.

Author: Sinha, D., Dasmandal, T., Paul, K., Yeasin, M., Bhattacharjee, S., Murmu, S., Mishra, D. C., Pal, S., Rai, A. and Archak, S.

2023

Annotation of gene sequence and protein structure of brinjal EDS1

Author: Soumya Sharma, Sarika Jaiswal, Sunil Archak

2017

Plant Virus Interaction Mechanism and Associated Pathways in Mosaic Disease of Green Cardamom (Elettaria cardamomum Maton) by RNA-Seq Approach

Author: Khan, Aamir, Johnson, George K, Jasrotia, Rahul Singh, Aravind, Sharon, Angadi, U. B., Iquebal, M.A., Manju KP, Jaiswal, Sarika, Umadevi P., Rai, Anil, Kumar, Dinesh

2020

BufAMPpred: Deep learning-based whole genome-wide antimicrobial peptide prediction tool in buffalo with its database.

Author: Khan, Aamir, Singh, Kalpana, Verma, Ajay, Jaiswal, Sarika, Nayan, Varij, Angadi, Ulavappa B., Datta, TK, Rai, Anil, Kumar, Dinesh, Iquebal, Mir Asif*

2026

Whole Genome based web genomic resource for water buffalo (Bubalus bubalis).

Author: Khan, Aamir Khan, Singh, Kalpana, Jaiswal, Sarika, Raza, Mustafa, Jasrotia, Rahul Singh, Kumar, Animesh, Gurjar, Anoop Kishor Singh, Kumari, Juli, Nayan, Varij, Iquebal, Mir Asif*, Angadi, U. B., Rai, Anil Rai, Datta, Tirtha Kumar, Kumar, Dinesh

2022

BuffExDb: Web-based tissue-specific gene expression resource for breeding and conservation programs in Bubalus bubalis.

Author: Kumari, Naina, Kumar, Samir, Roy, Anupama, Saini, Princy, Jaiswal, Sarika, Iquebal, Mir Asif, Angadi, U B, Kumar, Dinesh Kumar (2025) (https://academic.oup.com/database/article/doi/10.1093/database/baae128/7978825)

2025

Uncovering the Molecular Mechanisms of Bovine Tuberculosis Through Meta-Analysis of Differentially Expressed Genes.

Author: Kumari, Naina, Jaiswal, Sarika, Iquebal, Mir Asif, Kumar, Dinesh

2025

Development of a GWAS analysis method for detection of epistasis in crops

Author: Tanwy Dasmandal

2019-20

Epistasis, or interaction between genetic variations at two or more loci within or between genes, plays a critical role in shaping the genetic architecture of complex traits. However, detecting epistatic interactions remains a significant challenge in genome-wide association studies (GWAS), particularly in crop species where high-dimensional genomic data and polygenic regulation complicate signal identification. Existing epistasis detection approaches mostly focused on one of the two basic constraints of epistasis detection: computational efficiency or interaction detection power. In the present study the emphasis shifted towards developing a balanced machine learning based two-stage framework for robust epistasis detection in crops that reduces the computational burden without compromising the detection power and assessing their utility in genomic prediction. In the first stage i.e. the shortlisting stage, comparative analysis of machine learning algorithms, namely, Adaboost, Artificial Neural Networks, Random Forest, Stepwise Regression, Ridge Regression, LASSO, and Elastic Net on simulated datasets revealed ridge regression as most effective for shortlisting marginal SNPs and random forest for non-marginal SNPs. Stage two (epistasis detection stage) subjected shortlisted SNPs to information-theoretic (Information Gain, Maximal Information Coefficient) and statistical (Chi-square) interaction tests, uncovering both marginal and non-marginal epistatic interactions. Benchmarking against existing tools (MACOED, BEAM, BOOST) showed superior power and accuracy of the proposed method. The developed approach was also biologically validated on Glycine max dataset comprising 2,662 accessions, with days to flowering as the trait of interest. The analysis identified 102 marginal and 107 non-marginal epistatic interactions, including both intra- and inter-chromosomal links, highlighting the polygenic and networked regulation of flowering time. Importantly, genomic prediction models showed that incorporating epistatic loci improved accuracy from 78.07% (maineffect loci only) to 87.36%, underscoring the importance of accounting for epistasis in trait prediction. For implementation and practical application, the framework was encapsulated into a user-friendly R package named EpiFusion, incorporating dedicated modules for shortlisting and interaction detection. Overall, the study highlights the value of combining machine learning and statistical modeling for epistasis detection in crops and by providing a flexible, efficient, and biologically relevant framework, the developed approach not only advances methodological capabilities in GWAS but also contributes to precision breeding by strengthening the predictive power of genomic selection strategies.

MLDeCNV: A machine-learning approach for accurate detection of copy number variants from whole genome sequencing

Author: Das, Parinita, Saha, Bibek, Sharma, Nitesh Kumar, Iquebal, Mir Asif, Papanicolaou, Alexie, Angadi, U B, Kumar, Dinesh, Jaiswal, Sarika

2026

Pan-Genomics of Horticultural Crops: Unveiling the Complete Genetic Landscape for Crop Improvement

Author: Anupama Roy

Genomic resources and genetic improvement of vital tropical and subtropical fruit crops: current status and prospects

Author: Roy, Anupama, Chandra, Tilak, Mondal, Raju, Molla, Johiruddin, Jaiswal, Sarika, Srivastava, Manish, Kumar, Dinesh, Molla, Kutubuddin A., Iquebal, Mir Asif

2024

FEAtl: a comprehensive web-based expression atlas for functional genomics in tropical and subtropical fruit crops.

Author: Roy, Anupama, Chaurasia, Himanshushekhar, Kumar, Baibhav, Kumari, Naina; Jaiswal, Sarika, Srivastava, Manish, Kumar, Dinesh, Angadi, UB, Iquebal, Mir Asif (

2024